Praveen Arany

My primary interest is focused on clinical translation for wound healing and tissue regeneration.

Our group uses cell-molecular biology, biomaterials, and biomedical technologies, especially biophotonics and other directed energy approaches to modulate biological mechanisms. We aim to utilize our fundamental understanding of biological regulation to control therapeutic clinical outcomes.

The Arany lab is pursuing directed differentiation of stem cells using biomaterials-based scaffold systems. As a prototypical tissue, the lab is interested in outlining the precise biological and biophysical cues necessary for dentin regeneration. Inspired by embryonic development, their prior work has demonstrated the ability to generate spatio-temporally restricted morphogen fields using a combination of agonist (eg; growth factor) and antagonist (eg; neutralizing antibody) cues. A major emphasis in his group is to pursue molecular mechanisms driving this process to enable in vivo animal testing and human clinical translation.

Dr. Arany’s clinical translational research interests are focused on the therapeutic use of low dose biophotonics devices, termed low level light/laser therapy or Photobiomodulation Therapy. His prior work demonstrated a molecular therapeutic pathway activation of a latent growth factor, TGF-β1 that directed differentiation of dental and mesenchymal stem cells to form a lineage-restricted mineralized tissue, dentin. Further, his lab recently outlined key clinical and molecular biomarkers for safe and effective delivery of photobiomodulation therapy. His group is in the process of beginning clinical trials in human subjects to apply these observations to develop human therapy.