Articles on Modeling

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Genome-scale metabolic models capture the complex chemical reactions that allow cells to function. Yuri Arcurs/iStock via Getty Images Plus

Microbes can colonize space, produce drugs and create energy − researchers are simulating their inner workings to harness how

Using digital blueprints of the metabolism of microbes, scientists can simulate expensive and time-intensive experiments set in space, power plants and farm fields.
The sum is greater than the parts when researchers build an ensemble from multiple coordinated but independent models. Matteo Chinazzi

Pooling multiple models during COVID‑19 pandemic provided more reliable projections about an uncertain future

Policymakers rely on models during uncertain times to figure out how their choices could affect the future. Over the pandemic, an ensemble of many COVID-19 models outperformed any one alone.
The lung-on-a-chip can mimic both the physical and mechanical qualities of a human lung. Wyss Institute for Biologically Inspired Engineering, Harvard University/Flickr

Organ‑on‑a‑chip models allow researchers to conduct studies closer to real‑life conditions – and possibly grease the drug development pipeline

Successes in the lab mostly don’t translate to people. Research models that better mimic the human body could close the gap.
Common hazel dispersing pollen in early spring. Arterra/Universal Images Group via Getty Images

Achoo! 5 essential reads for pollen season

Pollen brings seasonal misery to millions of Americans, but it serves a critical purpose: fertilizing many kinds of plants, including food crops.
A November 2020 memorial in Washington, D.C. consisted of thousands of flags, each planted to remember someone who died of COVID-19. Andrew Lichtenstein/Corbis via Getty Images

578,555 people have died from COVID‑19 in the US, or maybe it’s 912,345 – here’s why it’s hard to count

Record-keepers have a pretty good sense of how many people have died. But figuring out the cause of those deaths is a lot trickier – and that’s why reasonable modelers can disagree.
Halston with the Halstonettes – a group of models who were part of his entourage – at the Metropolitan Museum of Art in New York City in 1980. Ron Galella/Ron Galella Collection via Getty Images

Halston: The glittering rise – and spectacular fall – of a fashion icon

The subject of a new Netflix miniseries, Halston once ruled over New York’s fashion world. But the designer with a devil-may-care approach to his business dealings attempted too much, too quickly.
Nurses and other health care workers in New York mourned colleagues who have died during the outbreak of the novel coronavirus. Johannes Eisele/AFP/Getty Images

Coronavirus deaths in San Francisco vs. New York: What causes such big differences in cities’ tolls?

Why one city suffers significantly more deaths than another isn’t always obvious. A simple experiment shows how failing to consider certain factors can point policy makers in the wrong direction.
An Indonesian island was home to H. Floresiensis – but how did the dwarfed human species evolve? areza taqwim/Shutterstock.com

Fast evolution explains the tiny stature of extinct ‘Hobbit’ from Flores Island

New research models how the Homo floresiensis species could have evolved its small size remarkably quickly while living on an isolated island.

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